Congenital condition manifested by palmar and plantar ulcerating lesions with osteolysis involving distal phalanges of the fingers and toes. Acquired acro-osteolysis has been reported in workers exposed to vinyl chloride. There is an autosomal disorder, Cheney’s syndrome [MIM*102500], in which this finding is combined with Wormian bones, hypolplasia of the mandibular rami and basilar osteoporosis. See Also: Cheney syndrome.


[acro- + G. osteon, bone, + lysis, loosening]

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