a form of histoplasmosis caused by Histoplasma capsulatum var. duboisii, observed only in tropical Africa; the organism grows chiefly in giant cells, causing lesions localized to skin, bone, or lacrimal glands, or is disseminated with multiple foci of osteomyelitis and visceral disorders; generalized forms produce lesions in lymph nodes, spleen, liver, bone, and lungs, although lung involvement is uncommon.